Amy Schumer is opening up—again—about her ongoing, candid weight loss journey. And this time, she’s feeling optimistic.
After years of public struggles with body image, hormone imbalance, and side effects from popular injectable weight-loss drugs, the 43-year-old comedian says she’s finally found something that actually works for her: Mounjaro.
In a recent Instagram video, Schumer didn’t hold back.
Speaking from the driver’s seat of her car, she shared how she’s now “having a really good experience” with the medication—after past attempts left her sick, sidelined, and searching for solutions.
Here’s what’s different now—and why her story is resonating with so many women.
Jump to:
- From Bedridden to Energized: A Tale of Two GLP-1s
- Enter Mounjaro: What Changed?
- Speaking Up Against Silence in Hollywood
- A History of Self-Defense Through Humor
- Athlete at Heart, Still Showing Up
- The Bigger Picture: Weight Loss Isn’t Just Aesthetic
- Mounjaro May Not Be for Everyone—But It’s Changing the Conversation
From Bedridden to Energized: A Tale of Two GLP-1s
Schumer’s previous experience with semaglutide-based drugs like Wegovy and Ozempic was far from successful.
“I was like puking, I couldn’t handle it,” she said, recalling her attempt to use Wegovy three years ago. She later revealed on “Watch What Happens Live” that Ozempic left her so ill she couldn’t play with her young son. “I was, like, bedridden… vomiting—and then you have no energy,” she said on Howard Stern’s Sirius XM show.
The medications, both FDA-approved for Type 2 diabetes and often prescribed off-label for weight loss, can cause gastrointestinal issues like nausea, vomiting, and diarrhea. While many s report appetite suppression and significant weight loss, Schumer’s side effects were too severe to ignore.
Enter Mounjaro: What Changed?
Mounjaro (tirzepatide) is a newer GLP-1 receptor agonist originally developed for managing blood sugar in people with Type 2 diabetes. Like Ozempic, it impacts insulin levels and appetite—but targets two hormone receptors instead of one, potentially boosting effectiveness.
For Schumer, the difference has been night and day.
“My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy,” she said. “I want to ‘get down’ more—I’m talking about sex.”
She also credited estrogen and progesterone therapy as key to her transformation. After a telehealth appointment through Midi Health, Schumer started hormone replacement therapy (HRT) to manage her perimenopausal symptoms.
“I liked it so much… I invested in the company,” she added, referring to the virtual clinic, which also counts Connie Britton, Brandi Chastain, and Sheryl Sandberg’s VC firm among its backers.
Speaking Up Against Silence in Hollywood
For Schumer, transparency is personal—and political. She’s long been critical of the secrecy surrounding body transformations in Hollywood.
“Everybody’s lying,” she said during her 2023 appearance on “Watch What Happens Live.” “Everyone’s like, ‘Oh, smaller portions.’ Like, shut the f–k up. You’re on Ozempic or one of those things. Or you got work done.”
That same year, she shared that after undergoing a hysterectomy, appendectomy, and C-section, she opted for liposuction—a decision she says was about feeling better in her body, not chasing perfection.
“It’s not about needing to be slamming,” she told The Hollywood Reporter. “But I’d reached a place where I was tired of looking at myself in the mirror… I just wanted to be real about it.”
A History of Self-Defense Through Humor
Schumer has used comedy as armor since childhood. In a sixth-grade moment that stuck with her for decades, a classmate called her “Big Bertha.” Instead of crying, she learned to deflect with humor.
“I would just fire back and make a joke myself. It was like training for a roast,” she told the Los Angeles Times.
But as her fame grew, so did the criticism. Despite her comedy specials, awards, and film roles, Schumer’s body became a constant topic—fueling her resolve to talk openly about her experiences.
“I want so much for women to love themselves and be relentless when fighting for their own health in a system that usually doesn’t believe them,” she wrote in a newsletter shared with People.
Athlete at Heart, Still Showing Up
Behind the scenes, Schumer works out like an athlete—because she is one. A former aerobics instructor who played sports throughout high school and college, she trains with celebrity coach Harley Pasternak and a longtime boxing trainer.
“She’s very coordinated and easy to push in the gym,” Pasternak told Health magazine.
Her go-to exercises include:
- Skater lunges
- Dumbbell curl presses
- Spider planks
- Supermans
- Hip thrust triceps extensions
She rounds out her routine on the Helix machine for cardio.
The Bigger Picture: Weight Loss Isn’t Just Aesthetic
For Schumer, weight loss isn’t about conforming to beauty standards—it’s about reclaiming energy, libido, and confidence during midlife.
Perimenopause, which can begin as early as the mid-30s, affects millions of women with symptoms like brain fog, low energy, irritability, and hot flashes. But it often goes undiagnosed or untreated.
Schumer’s openness is part of a growing wave of celebrities—including Oprah and Chelsea Handler—speaking out about hormonal health and new weight management tools.
Mounjaro May Not Be for Everyone—But It’s Changing the Conversation
Though Schumer is experiencing success with Mounjaro, she reminds followers that access is still limited. Insurance may not cover the drug unless someone is diagnosed with diabetes or clinically significant obesity.
“Which most of the internet thinks I have,” she joked, in classic Amy fashion.
Still, she’s grateful for the shift.
“I’m having a really good experience, so I wanted to keep it real with you about that.”
Her story reminds us that no two journeys are alike—but honesty, advocacy, and a little humor can go a long way.
